How do living architectures grow and persist? My research on life has sought to clarify how information flows between local and global scales.
Stiffness sensing in connective tissue
Certain types of cells actively probe and respond to stiffness. What a cell learn about its surroundings by pulling?
We investigated this type of sensing by modeling tissues as elastic networks. Our mechanical model revealed what a microscopic sensor can learn about tissue identity.
Physical limits to sensing material properties
Probing a messy material tells you something about local stiffness. How can a sensor best feel the overall stiffness?
The information gleaned by sensing is bounded by elasticity. Sensory multiplexing explains how to sense near these bounds.
Genome maintenance during aging
Over time, cells lose genes that encode protein factories. What might cells do to maintain enough genes to survive?
The Yamashita Lab and I explored stochastic equations of gene copy number. Our models showed that preferential inheritance can guard the fidelity of DNA during aging.