Stiffness sensing in connective tissue
Certain types of cells probe and respond to stiffness. What can cells learn by pulling on tissue networks?
We investigated cellular mechanosensing by simulating how biopolymers respond to force dipoles.
Physical limits to sensing material properties
Genome maintenance during aging
Over time, cells lose genes encoding protein-producing factories. What might cells do to maintain enough genes to survive?
The Yamashita Lab and I explored stochastic equations of gene copy number to learn how preferential inheritance can guard the fidelity of DNA during aging.