How do living architectures thrive and persist? My biophysical research sought to clarify how information flows between local and global scales.
Stiffness sensing in connective tissue
Certain types of cells actively probe and respond to stiffness. What a cell learn about its surroundings by pulling?
Physical limits to sensing material properties
How can information from a collection of localized sensors be combined to infer overall stiffness?
The information gleaned by sensing is bounded by elasticity. Sensory multiplexing explains how to sense near these bounds.
Genome maintenance during aging
Over time, cells lose genes that encode protein-producing factories. What might cells do to maintain enough genes to survive?
The Yamashita Lab and I explored stochastic equations of gene copy number to learn how preferential inheritance can guard the fidelity of DNA during aging.