How do living architectures thrive and persist? My biophysical research sought to clarify how information flows between local and global scales.

Architectural transitions in biofilms

Groups of sticky bacteria can grow into patterned ellipsoids. How do these complex structures arise?

A simple verticalizing-fluid model shows how the structures are governed by waves of localized mechanical instabilities.

Open source biofilm simulator

Stiffness sensing in connective tissue

Certain types of cells actively probe and respond to stiffness. What a cell learn about its surroundings by pulling?

We investigated cellular mechanosensing by simulating how tissue networks respond to force dipoles.

Study reveals ways in which cells feel their surroundings

Physical limits to sensing material properties

How can information from a collection of localized sensors be combined to infer overall stiffness?

The information gleaned by sensing is bounded by elasticity. Sensory multiplexing explains how to sense near these bounds.

Sensing in a disordered medium

Senti en malorda medio

Notebook to optimize a model sensor

Genome maintenance during aging

Over time, cells lose genes that encode protein-producing factories. What might cells do to maintain enough genes to survive?

The Yamashita Lab and I explored stochastic equations of gene copy number to learn how preferential inheritance can guard the fidelity of DNA during aging.